This genus contains most of the species formerly known as Epipedobates. The main synapomorphy uniting this clade is the presence of granular dorsal skin. Other characteristics include dorsolateral stripes, first finger longer than or equal in length to second finger, and somewhat large size (usually over 30 mm SVL). Most species in this genus are moderately toxic and aposematic. These species are distributed mainly throughout the east-Andean versant and east into the Amazon basin. Two species, A. andina and A. erythromos occur on the Pacific side of the Andes in Colombia, although their assignment to this genus is based on very limited data.

Species contained in Ameerega: