This subfamily was resurrected by Grant et al. (2006) to include most of the former (and present) Epipedobates, as well as a handful of other species. Synapomorphies include: first finger longer than second, third finger swollen in adult males (in some species), cephalic amplexus present.
Genera contained within Colostethinae:
- Ameerega (30 species)Bauer, 1988
- Colostethus (19 species)Cope, 1866
- Epipedobates (6 species)Myers, 1987
- Silverstoneia (3 species)Grant et al., 2006